Below is a list of our active studies, not including open-label extension studies.
▾ Adult Treatment-Resistant Major Depressive Disorder
A 4 week, double-blind trial of an NMDA receptor antagonist add-on investigational medication, compared to add-on placebo, which would be added to an already-approved antidepressant. Visits are multiple times per week.
▾ Adult Adjunctive Major Depressive Disorder
A 52 week, double-blind randomized-withdrawal trial of an atypical antipsychotic add-on investigational medication, compared to add-on placebo, which would be added to an already-approved antidepressant. Visits are weekly at first then spread out to monthly.
▾ Adult Major Depressive Disorder
An 8 week, double-blind trial of an NMDA receptor partial agonist investigational medication, compared to placebo, followed by a 4 month open-label period with only the investigational medication, followed by a 8 month randomized-withdrawal trial comparing the investigational medication to placebo. Visits are weekly.
▾ Adolescent Major Depressive Disorder
A 10 week, double-blind trial of an SSRI antidepressant that is already approved in adults, compared to one that is already approved in both adults, children, and adolescents, compared to placebo, followed by a 6 month, open-label trial of the first antidepressant. Visits are weekly or every other week.
▾ WHAT IS A CLINICAL TRIAL?
A clinical trial is a voluntary medical research study involving humans. In the case of Adams Clinical, all of the studies conducted are to test drugs made by pharmaceutical companies. In the United States, pharmaceutical companies are not permitted to evaluate whether their own drugs are safe and effective, so a neutral third-party such as Adams Clinical must handle all aspects of the testing. This third party has tight restrictions on its financial involvement in the pharmaceutical company and would face substantial criminal penalties for violating these limits.
There are four kinds of clinical trials performed in humans: Phase I, Phase II, Phase III, Phase IV. A drug must successfully pass through one phase in order to be approved for the next. Adams Clinical conducts mostly Phase III studies, but it occasionally will also conduct Phase II and Phase IV studies. Phase I studies are designed primarily to test whether a drug is safe. Phase II studies are designed primarily to test the efficacy of a drug. Phase III studies are designed primarily to confirm the positive results of the safety and efficacy of a drug among a much larger group of people.
Generally, when two Phase III studies reveal positive results for a drug, it may be submitted for approval with the Food and Drug Administration. Phase IV studies are performed after the FDA has approved a drug, and these studies are designed to reveal additional information about a drug beyond basic safety and efficacy information.
▾ WHY SHOULD I PARTICIPATE IN A CLINICAL TRIAL?
There are three reasons to participate in our clinical trials: to receive medical information, compensation, and altruism.
Medical information. Every participant in our clinical trials is given a medical evaluation, with a minimum of a medical and psychiatric examination, electrocardiogram, and an analysis of your blood chemistry by several physicians.
Compensation. Participating in a clinical trial is free. Participants are also compensated $50 to $125 for time and travel, with the exact amount varying in each study.
Altruism. Your participating in a clinical trial will make a difference in the field of psychiatry. The results of these studies will provide future patients with detailed information on the benefits and risks of drugs.
▾ HOW MUCH DOES IT COST TO PARTICIPATE?
Participating in a clinical trial is free. Every participant in our clinical trials is given some level of free medical care, with a minimum of a medical and psychiatric examination and an analysis of your blood chemistry. Participants are also compensated $50 to $125 per visit for time and travel, with the exact number of visits per month and amount varying in each study.
▾ DO I NEED HEALTH INSURANCE TO PARTICIPATE?
No, you do not need health insurance to participate.
▾ DO I QUALIFY TO PARTICIPATE?
Each study has different requirements in order to participate. After calling us or applying online, a doctor from our facility will call you to tell you more.
▾ WHAT HAPPENS IF I WANT TO STOP PARTICIPATING IN A TRIAL?
Clinical trials are completely voluntary. You may decide you no longer want to participate at any time at no cost.
▾ IS YOUR OFFICE ACCESSIBLE BY PUBLIC TRANSPORTATION?
Yes, our office is easily accessible by public transportation. You can also call us at any time at 617-744-8542 to schedule an Uber to pick you up. If you prefer public transportation you should take the 71 bus–which travels from Harvard Square to Watertown Square–which has a stop right outside of our office. The 71 bus picks up in Harvard Square right inside the MBTA station red-line stop. If you are coming from Harvard Square our stop is Upland Road and is immediately after the Lloyd Road stop.
Our address is 521 Mount Auburn Street, Suites 107, 109, 203, 209, Watertown, MA 02472.